Biologically active oligodeoxyribonucleotides—IX.1 Synthesis and anti-HIV-1 activity of hexadeoxyribonucleotides, TGGGAG, bearing 3′- and 5′-end-modification
Identifieur interne : 003C86 ( Main/Exploration ); précédent : 003C85; suivant : 003C87Biologically active oligodeoxyribonucleotides—IX.1 Synthesis and anti-HIV-1 activity of hexadeoxyribonucleotides, TGGGAG, bearing 3′- and 5′-end-modification
Auteurs : Makoto Koizumi [Japon] ; Rika Koga [Japon] ; Hitoshi Hotoda [Japon] ; Kenji Momota [Japon] ; Toshinori Ohmine [Japon] ; Hidehiko Furukawa [Japon] ; Toshinori Agatsuma [Japon] ; Takashi Nishigaki [Japon] ; Koji Abe [Japon] ; Toshiyuki Kosaka [Japon] ; Shinya Tsutsumi [Japon] ; Junko Sone [Japon] ; Masakatsu Kaneko [Japon] ; Satoshi Kimura [Japon] ; Kaoru Shimada [Japon]Source :
- Bioorganic & Medicinal Chemistry [ 0968-0896 ] ; 1997.
Descripteurs français
- KwdFr :
- Agents antiVIH (pharmacologie), Agents antiVIH (synthèse chimique), Animaux, Conformation d'acide nucléique, Dichroïsme circulaire, Humains, Lignée cellulaire, Modèles chimiques, Oligodésoxyribonucléotides (pharmacologie), Oligodésoxyribonucléotides (synthèse chimique), Rats, Souris, VIH-1 (Virus de l'Immunodéficience Humaine de type 1) ().
- MESH :
- pharmacologie : Agents antiVIH, Oligodésoxyribonucléotides.
- synthèse chimique : Agents antiVIH, Oligodésoxyribonucléotides.
- Animaux, Conformation d'acide nucléique, Dichroïsme circulaire, Humains, Lignée cellulaire, Modèles chimiques, Rats, Souris, VIH-1 (Virus de l'Immunodéficience Humaine de type 1).
English descriptors
- KwdEn :
- MESH :
- chemical , chemical synthesis : Anti-HIV Agents, Oligodeoxyribonucleotides.
- chemical , pharmacology : Anti-HIV Agents, Oligodeoxyribonucleotides.
- drug effects : HIV-1.
- Teeft :
- Acetic anhydride, Acid hydrolysis, Alkaline conditions, Anhydride, Animals, Aqueous ammonia, Aqueous nahco3, Aromatic groups, Best candidate, Cell Line, Ch3cn, Chain length, Circular Dichroism, Column chromatography, Cpgs, Cytopathic effect, Cytotoxicity, Dichloroacetic acid, Dmtr, Dmtr group, Dmtr loading levels, Elsevier science, Enzymatic stability, Ethylene glycol, Experimental section, Furukawa, High activity, Higher activity, Hplc, Human plasma, Humans, Insoluble material, Loading level, Makoto koizumi, Mass spectroscopy, Methylphosphate group, Methylthiophosphate group, Mice, Mmol, Models, Chemical, Nucleic Acid Conformation, Nucleic acids, Odns, Open circles, Pentachlorophenyl ester, Phase hplc, Phosphate groups, Phosphorothioate bonds, Phosphorothioate modification, Pore glass, Pyridine, Quadruplex, Quadruplex structure, Rats, Reaction mixture, Retention time, Similar procedure, Snake venom phosphodiesterase, Solid squares, Succinate linker, Succinic anhydride, Succinyl anhydride, Sulfurization step, Ternary structure, Tetraethylthiuram disulfide, Tetrahedron lett, Triethylammonium acetate, Trityl cation.
Abstract
Abstract: We have determined that hexadeoxyribonucleotides (5′TGGGAG3′), with modified aromatic groups such as a trityl group at the 5′-end, have anti-HIV-1 activity in vitro. The 6-mer bearing a 3,4-dibenzyloxybenzyl (3,4-DBB) group at the 5′-end had the most potent activity and the least cytotoxicity. When the 3′-end of the 5′-(3,4-DBB)-modified 6-mer was substituted with a 2-hydroxyethylphosphate, a 2-hydroxyethylthiophosphate, or a methylphosphate group at the 3′-end, anti-HIV-1 activity increased. Moreover, among various 3′- and 5′-end-modified 6-mers that were tested, the 6-mer (R-95288) bearing a 3,4-DBB group at the 5′-end and a 2-hydroxyethylphosphate group at the 3′-end was the most stable, when incubated with mouse, rat, or human plasma. Therefore, R-95288 was chosen as the best candidate for possible use in therapy on the basis of its anti-HIV-1 activity.
A 6-mer (R-95288) bearing a 3,4-dibenzyloxybenzyl group at the 5′-end and a 2-hydroxyethylphosphate group at the 3′-end with anti-HIV-1 activity is described.gr1
Url:
DOI: 10.1016/S0968-0896(97)00161-2
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000192
- to stream Istex, to step Curation: 000192
- to stream Istex, to step Checkpoint: 001461
- to stream Main, to step Merge: 003D41
- to stream PubMed, to step Corpus: 002704
- to stream PubMed, to step Curation: 002704
- to stream PubMed, to step Checkpoint: 002598
- to stream Ncbi, to step Merge: 002B00
- to stream Ncbi, to step Curation: 002B00
- to stream Ncbi, to step Checkpoint: 002B00
- to stream Main, to step Merge: 003C86
- to stream Main, to step Curation: 003C86
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Biologically active oligodeoxyribonucleotides—IX.1 Synthesis and anti-HIV-1 activity of hexadeoxyribonucleotides, TGGGAG, bearing 3′- and 5′-end-modification</title><author><name sortKey="Koizumi, Makoto" sort="Koizumi, Makoto" uniqKey="Koizumi M" first="Makoto" last="Koizumi">Makoto Koizumi</name></author><author><name sortKey="Koga, Rika" sort="Koga, Rika" uniqKey="Koga R" first="Rika" last="Koga">Rika Koga</name></author><author><name sortKey="Hotoda, Hitoshi" sort="Hotoda, Hitoshi" uniqKey="Hotoda H" first="Hitoshi" last="Hotoda">Hitoshi Hotoda</name></author><author><name sortKey="Momota, Kenji" sort="Momota, Kenji" uniqKey="Momota K" first="Kenji" last="Momota">Kenji Momota</name></author><author><name sortKey="Ohmine, Toshinori" sort="Ohmine, Toshinori" uniqKey="Ohmine T" first="Toshinori" last="Ohmine">Toshinori Ohmine</name></author><author><name sortKey="Furukawa, Hidehiko" sort="Furukawa, Hidehiko" uniqKey="Furukawa H" first="Hidehiko" last="Furukawa">Hidehiko Furukawa</name></author><author><name sortKey="Agatsuma, Toshinori" sort="Agatsuma, Toshinori" uniqKey="Agatsuma T" first="Toshinori" last="Agatsuma">Toshinori Agatsuma</name></author><author><name sortKey="Nishigaki, Takashi" sort="Nishigaki, Takashi" uniqKey="Nishigaki T" first="Takashi" last="Nishigaki">Takashi Nishigaki</name></author><author><name sortKey="Abe, Koji" sort="Abe, Koji" uniqKey="Abe K" first="Koji" last="Abe">Koji Abe</name></author><author><name sortKey="Kosaka, Toshiyuki" sort="Kosaka, Toshiyuki" uniqKey="Kosaka T" first="Toshiyuki" last="Kosaka">Toshiyuki Kosaka</name></author><author><name sortKey="Tsutsumi, Shinya" sort="Tsutsumi, Shinya" uniqKey="Tsutsumi S" first="Shinya" last="Tsutsumi">Shinya Tsutsumi</name></author><author><name sortKey="Sone, Junko" sort="Sone, Junko" uniqKey="Sone J" first="Junko" last="Sone">Junko Sone</name></author><author><name sortKey="Kaneko, Masakatsu" sort="Kaneko, Masakatsu" uniqKey="Kaneko M" first="Masakatsu" last="Kaneko">Masakatsu Kaneko</name></author><author><name sortKey="Kimura, Satoshi" sort="Kimura, Satoshi" uniqKey="Kimura S" first="Satoshi" last="Kimura">Satoshi Kimura</name></author><author><name sortKey="Shimada, Kaoru" sort="Shimada, Kaoru" uniqKey="Shimada K" first="Kaoru" last="Shimada">Kaoru Shimada</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:4F39626F74C4CDA393DAB8E9E7DFF9E1EE61A174</idno><date when="1997" year="1997">1997</date><idno type="doi">10.1016/S0968-0896(97)00161-2</idno><idno type="url">https://api.istex.fr/ark:/67375/6H6-DSB3ZTHB-K/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000192</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000192</idno><idno type="wicri:Area/Istex/Curation">000192</idno><idno type="wicri:Area/Istex/Checkpoint">001461</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001461</idno><idno type="wicri:doubleKey">0968-0896:1997:Koizumi M:biologically:active:oligodeoxyribonucleotides</idno><idno type="wicri:Area/Main/Merge">003D41</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:9459021</idno><idno type="wicri:Area/PubMed/Corpus">002704</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002704</idno><idno type="wicri:Area/PubMed/Curation">002704</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002704</idno><idno type="wicri:Area/PubMed/Checkpoint">002598</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002598</idno><idno type="wicri:Area/Ncbi/Merge">002B00</idno><idno type="wicri:Area/Ncbi/Curation">002B00</idno><idno type="wicri:Area/Ncbi/Checkpoint">002B00</idno><idno type="wicri:doubleKey">0968-0896:1997:Koizumi M:biologically:active:oligodeoxyribonucleotides</idno><idno type="wicri:Area/Main/Merge">003C86</idno><idno type="wicri:Area/Main/Curation">003C86</idno><idno type="wicri:Area/Main/Exploration">003C86</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Biologically active oligodeoxyribonucleotides—IX.1 Synthesis and anti-HIV-1 activity of hexadeoxyribonucleotides, TGGGAG, bearing 3′- and 5′-end-modification</title><author><name sortKey="Koizumi, Makoto" sort="Koizumi, Makoto" uniqKey="Koizumi M" first="Makoto" last="Koizumi">Makoto Koizumi</name><affiliation wicri:level="1"><country wicri:rule="url">Japon</country></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Exploratory Chemistry Research Laboratory, Sankyo Co., Ltd, Tokyo 140</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Koga, Rika" sort="Koga, Rika" uniqKey="Koga R" first="Rika" last="Koga">Rika Koga</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Exploratory Chemistry Research Laboratory, Sankyo Co., Ltd, Tokyo 140</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Hotoda, Hitoshi" sort="Hotoda, Hitoshi" uniqKey="Hotoda H" first="Hitoshi" last="Hotoda">Hitoshi Hotoda</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Exploratory Chemistry Research Laboratory, Sankyo Co., Ltd, Tokyo 140</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Momota, Kenji" sort="Momota, Kenji" uniqKey="Momota K" first="Kenji" last="Momota">Kenji Momota</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Biological Research Laboratory, Sankyo Co., Ltd, Tokyo 140</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Ohmine, Toshinori" sort="Ohmine, Toshinori" uniqKey="Ohmine T" first="Toshinori" last="Ohmine">Toshinori Ohmine</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Biological Research Laboratory, Sankyo Co., Ltd, Tokyo 140</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Furukawa, Hidehiko" sort="Furukawa, Hidehiko" uniqKey="Furukawa H" first="Hidehiko" last="Furukawa">Hidehiko Furukawa</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Biological Research Laboratory, Sankyo Co., Ltd, Tokyo 140</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Agatsuma, Toshinori" sort="Agatsuma, Toshinori" uniqKey="Agatsuma T" first="Toshinori" last="Agatsuma">Toshinori Agatsuma</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Biological Research Laboratory, Sankyo Co., Ltd, Tokyo 140</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Nishigaki, Takashi" sort="Nishigaki, Takashi" uniqKey="Nishigaki T" first="Takashi" last="Nishigaki">Takashi Nishigaki</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Biological Research Laboratory, Sankyo Co., Ltd, Tokyo 140</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Abe, Koji" sort="Abe, Koji" uniqKey="Abe K" first="Koji" last="Abe">Koji Abe</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Analytical and Metabolic Research Laboratory, Sankyo Co., Ltd, Tokyo 140</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Kosaka, Toshiyuki" sort="Kosaka, Toshiyuki" uniqKey="Kosaka T" first="Toshiyuki" last="Kosaka">Toshiyuki Kosaka</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Analytical and Metabolic Research Laboratory, Sankyo Co., Ltd, Tokyo 140</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Tsutsumi, Shinya" sort="Tsutsumi, Shinya" uniqKey="Tsutsumi S" first="Shinya" last="Tsutsumi">Shinya Tsutsumi</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Analytical and Metabolic Research Laboratory, Sankyo Co., Ltd, Tokyo 140</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Sone, Junko" sort="Sone, Junko" uniqKey="Sone J" first="Junko" last="Sone">Junko Sone</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Analytical and Metabolic Research Laboratory, Sankyo Co., Ltd, Tokyo 140</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Kaneko, Masakatsu" sort="Kaneko, Masakatsu" uniqKey="Kaneko M" first="Masakatsu" last="Kaneko">Masakatsu Kaneko</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Exploratory Chemistry Research Laboratory, Sankyo Co., Ltd, Tokyo 140</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Kimura, Satoshi" sort="Kimura, Satoshi" uniqKey="Kimura S" first="Satoshi" last="Kimura">Satoshi Kimura</name><affiliation wicri:level="4"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo 108</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName><orgName type="university">Université de Tokyo</orgName><placeName><settlement type="city">Tokyo</settlement><region type="province">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Shimada, Kaoru" sort="Shimada, Kaoru" uniqKey="Shimada K" first="Kaoru" last="Shimada">Kaoru Shimada</name><affiliation wicri:level="4"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo 108</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName><orgName type="university">Université de Tokyo</orgName><placeName><settlement type="city">Tokyo</settlement><region type="province">Région de Kantō</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Bioorganic & Medicinal Chemistry</title><title level="j" type="abbrev">BMC</title><idno type="ISSN">0968-0896</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1997">1997</date><biblScope unit="volume">5</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="2235">2235</biblScope><biblScope unit="page" to="2243">2243</biblScope></imprint><idno type="ISSN">0968-0896</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0968-0896</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Anti-HIV Agents (chemical synthesis)</term><term>Anti-HIV Agents (pharmacology)</term><term>Cell Line</term><term>Circular Dichroism</term><term>HIV-1 (drug effects)</term><term>Humans</term><term>Mice</term><term>Models, Chemical</term><term>Nucleic Acid Conformation</term><term>Oligodeoxyribonucleotides (chemical synthesis)</term><term>Oligodeoxyribonucleotides (pharmacology)</term><term>Rats</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Agents antiVIH (pharmacologie)</term><term>Agents antiVIH (synthèse chimique)</term><term>Animaux</term><term>Conformation d'acide nucléique</term><term>Dichroïsme circulaire</term><term>Humains</term><term>Lignée cellulaire</term><term>Modèles chimiques</term><term>Oligodésoxyribonucléotides (pharmacologie)</term><term>Oligodésoxyribonucléotides (synthèse chimique)</term><term>Rats</term><term>Souris</term><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1) ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemical synthesis" xml:lang="en"><term>Anti-HIV Agents</term><term>Oligodeoxyribonucleotides</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-HIV Agents</term><term>Oligodeoxyribonucleotides</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>HIV-1</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Agents antiVIH</term><term>Oligodésoxyribonucléotides</term></keywords><keywords scheme="MESH" qualifier="synthèse chimique" xml:lang="fr"><term>Agents antiVIH</term><term>Oligodésoxyribonucléotides</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Acetic anhydride</term><term>Acid hydrolysis</term><term>Alkaline conditions</term><term>Anhydride</term><term>Animals</term><term>Aqueous ammonia</term><term>Aqueous nahco3</term><term>Aromatic groups</term><term>Best candidate</term><term>Cell Line</term><term>Ch3cn</term><term>Chain length</term><term>Circular Dichroism</term><term>Column chromatography</term><term>Cpgs</term><term>Cytopathic effect</term><term>Cytotoxicity</term><term>Dichloroacetic acid</term><term>Dmtr</term><term>Dmtr group</term><term>Dmtr loading levels</term><term>Elsevier science</term><term>Enzymatic stability</term><term>Ethylene glycol</term><term>Experimental section</term><term>Furukawa</term><term>High activity</term><term>Higher activity</term><term>Hplc</term><term>Human plasma</term><term>Humans</term><term>Insoluble material</term><term>Loading level</term><term>Makoto koizumi</term><term>Mass spectroscopy</term><term>Methylphosphate group</term><term>Methylthiophosphate group</term><term>Mice</term><term>Mmol</term><term>Models, Chemical</term><term>Nucleic Acid Conformation</term><term>Nucleic acids</term><term>Odns</term><term>Open circles</term><term>Pentachlorophenyl ester</term><term>Phase hplc</term><term>Phosphate groups</term><term>Phosphorothioate bonds</term><term>Phosphorothioate modification</term><term>Pore glass</term><term>Pyridine</term><term>Quadruplex</term><term>Quadruplex structure</term><term>Rats</term><term>Reaction mixture</term><term>Retention time</term><term>Similar procedure</term><term>Snake venom phosphodiesterase</term><term>Solid squares</term><term>Succinate linker</term><term>Succinic anhydride</term><term>Succinyl anhydride</term><term>Sulfurization step</term><term>Ternary structure</term><term>Tetraethylthiuram disulfide</term><term>Tetrahedron lett</term><term>Triethylammonium acetate</term><term>Trityl cation</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Conformation d'acide nucléique</term><term>Dichroïsme circulaire</term><term>Humains</term><term>Lignée cellulaire</term><term>Modèles chimiques</term><term>Rats</term><term>Souris</term><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1)</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: We have determined that hexadeoxyribonucleotides (5′TGGGAG3′), with modified aromatic groups such as a trityl group at the 5′-end, have anti-HIV-1 activity in vitro. The 6-mer bearing a 3,4-dibenzyloxybenzyl (3,4-DBB) group at the 5′-end had the most potent activity and the least cytotoxicity. When the 3′-end of the 5′-(3,4-DBB)-modified 6-mer was substituted with a 2-hydroxyethylphosphate, a 2-hydroxyethylthiophosphate, or a methylphosphate group at the 3′-end, anti-HIV-1 activity increased. Moreover, among various 3′- and 5′-end-modified 6-mers that were tested, the 6-mer (R-95288) bearing a 3,4-DBB group at the 5′-end and a 2-hydroxyethylphosphate group at the 3′-end was the most stable, when incubated with mouse, rat, or human plasma. Therefore, R-95288 was chosen as the best candidate for possible use in therapy on the basis of its anti-HIV-1 activity.</div><div type="abstract">A 6-mer (R-95288) bearing a 3,4-dibenzyloxybenzyl group at the 5′-end and a 2-hydroxyethylphosphate group at the 3′-end with anti-HIV-1 activity is described.gr1 </div></front></TEI><affiliations><list><country><li>Japon</li></country><region><li>Région de Kantō</li></region><settlement><li>Tokyo</li></settlement><orgName><li>Université de Tokyo</li></orgName></list><tree><country name="Japon"><noRegion><name sortKey="Koizumi, Makoto" sort="Koizumi, Makoto" uniqKey="Koizumi M" first="Makoto" last="Koizumi">Makoto Koizumi</name></noRegion><name sortKey="Abe, Koji" sort="Abe, Koji" uniqKey="Abe K" first="Koji" last="Abe">Koji Abe</name><name sortKey="Agatsuma, Toshinori" sort="Agatsuma, Toshinori" uniqKey="Agatsuma T" first="Toshinori" last="Agatsuma">Toshinori Agatsuma</name><name sortKey="Furukawa, Hidehiko" sort="Furukawa, Hidehiko" uniqKey="Furukawa H" first="Hidehiko" last="Furukawa">Hidehiko Furukawa</name><name sortKey="Hotoda, Hitoshi" sort="Hotoda, Hitoshi" uniqKey="Hotoda H" first="Hitoshi" last="Hotoda">Hitoshi Hotoda</name><name sortKey="Kaneko, Masakatsu" sort="Kaneko, Masakatsu" uniqKey="Kaneko M" first="Masakatsu" last="Kaneko">Masakatsu Kaneko</name><name sortKey="Kimura, Satoshi" sort="Kimura, Satoshi" uniqKey="Kimura S" first="Satoshi" last="Kimura">Satoshi Kimura</name><name sortKey="Koga, Rika" sort="Koga, Rika" uniqKey="Koga R" first="Rika" last="Koga">Rika Koga</name><name sortKey="Koizumi, Makoto" sort="Koizumi, Makoto" uniqKey="Koizumi M" first="Makoto" last="Koizumi">Makoto Koizumi</name><name sortKey="Kosaka, Toshiyuki" sort="Kosaka, Toshiyuki" uniqKey="Kosaka T" first="Toshiyuki" last="Kosaka">Toshiyuki Kosaka</name><name sortKey="Momota, Kenji" sort="Momota, Kenji" uniqKey="Momota K" first="Kenji" last="Momota">Kenji Momota</name><name sortKey="Nishigaki, Takashi" sort="Nishigaki, Takashi" uniqKey="Nishigaki T" first="Takashi" last="Nishigaki">Takashi Nishigaki</name><name sortKey="Ohmine, Toshinori" sort="Ohmine, Toshinori" uniqKey="Ohmine T" first="Toshinori" last="Ohmine">Toshinori Ohmine</name><name sortKey="Shimada, Kaoru" sort="Shimada, Kaoru" uniqKey="Shimada K" first="Kaoru" last="Shimada">Kaoru Shimada</name><name sortKey="Sone, Junko" sort="Sone, Junko" uniqKey="Sone J" first="Junko" last="Sone">Junko Sone</name><name sortKey="Tsutsumi, Shinya" sort="Tsutsumi, Shinya" uniqKey="Tsutsumi S" first="Shinya" last="Tsutsumi">Shinya Tsutsumi</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003C86 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003C86 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= MersV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:4F39626F74C4CDA393DAB8E9E7DFF9E1EE61A174
|texte= Biologically active oligodeoxyribonucleotides—IX.1 Synthesis and anti-HIV-1 activity of hexadeoxyribonucleotides, TGGGAG, bearing 3′- and 5′-end-modification
}}
| This area was generated with Dilib version V0.6.33. |  |